Abstract #3078

Location-wise Harmonization along White Matter Tracts on Neonatal Brain from Multiple Acquisition Protocols

Simin Liu^1,2,3, Xianjun Li¹, Miaomiao Wang¹, Chao Jin¹, Hua Guo³, and Jian Yang^1,2

¹Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China, ²Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China, ³Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

In this work, we proposed white matter location-wise harmonization of DTI measurement on neonatal brain based on tract quantification from multiple acquisition protocols. A total of 120 term neonates examined by two DTI acquisition protocols, including 38 neonates with punctate white matter lesions and 82 without MRI abnormalities, were enrolled. Two methods, Scaling and ComBat, were adopted, each carried out also on global-wise and ROI-wise in addition to location-wise. We also proposed an evaluation framework to systematically compare the adopted harmonization approaches, which suggests the way to select the utmost harmonization level and the specific method.

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