Abstract #3108

Disentangling the Effects of Anisotropy and Orientation Dispersion Using Diffusion Spherical Mean Spectrum Imaging

Tiantian Xu¹, Geng Chen¹, Haiyong Wu^1,2, Weili Lin¹, Dinggang Shen^1,3, and Pew-Thian Yap¹

¹University of North Carolina, Chapel Hill, NC, United States, ²Xiaozhuang University, Nanjing, China, ³Korea University, Seoul, Korea, Democratic People's Republic of

Diffusion fractional anisotropy (FA) measures voxel-level anisotropy, which mingles the effects of neurite microscopic-level anisotropy and orientation dispersion. We introduce a technique, called spherical mean spectrum imaging (SMSI), that can disentangle these two effects. We applied SMSI on baby brain diffusion MRI data collected during the first year of life and show that SMSI can extract microstructural information that is elusive to diffusion tensor imaging (DTI).

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