Abstract #3109

Quantification of white matter pathologies during multiple sclerosis disease development

Chunyu Song¹, Peng Sun², Anne H. Cross³, and Sheng-Kwei Song⁴

¹Biomedical Engineering, Washington University in St. Louis, st louis, MO, United States, ²Radiology, Washington University in St. Louis, st louis, MO, United States, ³Neurology, Washington University in St. Louis, st louis, MO, United States, ⁴The Hope Center for Neurological Disorders, Washington University in St. Louis, St Louis, MO, United States

A new diffusion MRI histology (D-Histo) is proposed to model both intra and extra axonal diffusion, in addition to isotropic diffusion. It not only resolves crossing fibers but also quantitatively assess axonal injury, axon loss, demyelination, edema and inflammation. Through the multiple-tensor modelling of diffusion-weighted MRI signals, D-Histo has shown promise to monitor evolving pathologies in normal appearing corpus callosum in multiple sclerosis patient brain.

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