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Abstract #3110

Determining how varying the number of gradient strengths and frequencies affects fitted mean axon diameters in the corpus callosum using oscillating spin echo gradients

Morgan Mercredi1, Sheryl L Herrera1, Richard Buist2, Kant Matsuda3, and Melanie Martin1,4

1Physics and Astronomy, University of Manitoba, Winnipeg, MB, Canada, 2Radiology, University of Manitoba, Winnipeg, MB, Canada, 3Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 4Physics, University of Winnipeg, Winnipeg, MB, Canada

There is an increasing drive to use diffusion spectroscopy to infer the sizes of structures in samples. We present here the first use of the sine OGSE to infer the effective mean axon diameters in the human corpus callosum and study the effect on accuracy of reducing the number of images used in the inference. Aiming to reduce imaging times, this study examines how the number of frequencies or number of gradients affects accuracy and precision. We found that collecting OGSE data with two gradients gives a difference in results of less than 5% compared to six gradients.

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