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Abstract #3111

Exchange arising from myelin water revealed from temperature-dependent multiexponential T2 mapping

Noam Shemesh1 and Mark D Does2

1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

The importance of myelin water exchange in relaxation and diffusion metrics extracted from tissues is still an open question. In particular, to what extent myelin water fraction (MWF) values derived from multiexponential T2 are due to exchange between myelin and intra/extra axonal spaces remains unclear. Here, fixed rat spinal cords were subject to temperature-dependent multiple spin echo experiments, aiming to probe how exchange modulates quantitative T2 maps in rat spinal cords. We find signatures for exchange from T2 shift patterns, which are tightly linked to the axon diameters in the spinal cord.

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