Abstract #3117

Stromal collagen content correlates with fast diffusivity signal fraction in breast lesions

Liv Egnell^1,2, Igor Vidić¹, Dennis W. Adams, Jr.³, Neil P. Jerome^2,4, Torill E. Sjøbakk⁴, Agnes Østlie², Hans E. Fjøsne^5,6, Rebecca Rakow-Penner⁷, Anders M. Dale^7,8, Anna M. Bofin⁹, Tone F. Bathen⁴, and Pål Erik Goa^1,2

¹Department of Physics, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, ²Clinic of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway, ³Department of Pathology, University of California San Diego School of Medicine, San Diego, CA, United States, ⁴Department of Circulation and Medical Imaging, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, ⁵Department of Cancer Research and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, ⁶Department of Surgery, St. Olavs University Hospital, Trondheim, Norway, ⁷Department of Radiology, University of California, San Diego, La Jolla, CA, United States, ⁸Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States, ⁹Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway

The deviation from a monoexponential of the DW-signal decay towards higher b-values (>1000s/mm²) reflects the complex tissue microstructure. The biexponential decay model assumes that the signal is composed of two components with different diffusivity, possibly originating from two physically separated tissue components. In this study, we estimate the collagenous and non-collagenous extracellular contents in sixteen breast lesions using hematoxylin-eosin-saffron stained histological specimens and compare with pre-surgical in vivo DW-MRI data. Our results show that the signal fraction of the faster diffusivity component correlated significantly with collagen content, suggesting that collagen contributes to the DWI signal decay

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