Abstract #3118

Multimodal microstructure imaging: joint T2-relaxometry and diffusometry to estimate myelin, intracellular, extracellular, and cerebrospinal fluid properties

Marco Pizzolato¹, Erick Jorge Canales-Rodríguez^1,2, Alessandro Daducci^1,2,3, and Jean-Philippe Thiran¹

¹Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Radiology Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, ³Computer Science Department, University of Verona, Verona, Italy

We propose a multimodal joint estimation that aims at exploiting the complementary information of diffusion and multi-echo spin echo data to disentangle the contributions and properties of the main tissue microstructure compartments. We recovered T2, diffusion coefficient, and volume fractions values of myelin, intracellular, extracellular, and cerebrospinal fluid compartments within an ex vivo spinal cord sample by means of diffusometry and relaxometry. A g-ratio map was also calculated.

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