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Abstract #3125

Clinical feasibility of Quantitative Susceptibility Mapping with Automatic Uniform Cerebrospinal Fluid Zero Reference

Shun Zhang1,2, Zhe Liu2,3, Yihao Yao1, Thanh D. Nguyen2, Pascal Spincemaille2, and Yi Wang2,3

1Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Radiolgy, Weill Cornell Medical College, NewYork, NY, United States, 3Biomedical Engineerring, Cornell University, Ithaca, NY, United States

Longitudinal and cross-center studies using conventional quantitative susceptibility mapping (QSM) methods require the choice of a reference tissue, its manual segmentation and subtraction of its average. In this work, we report our initial clinical experience with a fully automated zero-referenced Morphology Enabled Dipole Inversion (MEDI+0) method that uses the ventricular cerebrospinal fluid (CSF) as zero reference in 393 consecutive patients. In 92.62% of cases, excellent agreement of image quality between MEDI+0 and MEDI was observed with high correlation of lesion susceptibility in a combined glioma, ischemic stroke and multiple sclerosis subset of patients.

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