Abstract #3126

Thalamus in schizophrenia revisited: a partial-volume estimation study

Philipp S. Baumann^1,2, Elena Najdenovska^3,4, Mário João Fartaria^4,5, Alessandra Griffa³, Timo Roine^2,3,4, Yasser Alemán-Gómez^2,3,4, Emeline Mullier³, Philippe Golay¹, Zita Rovo², Patric Hagmann³, Kim Q. Do², Philippe Conus¹, Pascal Steullet², and Meritxell Bach Cuadra^3,4,6

¹Service of General Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ²Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ³Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁴Medical Image Analysis Laboratory (MIAL), Centre d'Imagerie BioMédicale (CIBM), Lausanne, Switzerland, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁶Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

The thalamus has a central role in the pathophysiology of schizophrenia. Formed by several nuclei, it is mainly constituted by a mixture of grey and white matter and, thus, its MR signal is heavily affected by the partial volume (PV) effect. We hypothesize that tissue segmentation based on a PV model will better depict subtle changes in schizophrenia patients than total thalamus volume or local tissue volume measurements that do not consider PV. Results show statistically significant changes in gray matter and white matter average concentration from PV model within the thalamus in schizophrenia patients (SCHZ) compared to healthy controls (HC).

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