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Abstract #3126

Thalamus in schizophrenia revisited: a partial-volume estimation study

Philipp S. Baumann1,2, Elena Najdenovska3,4, Mário João Fartaria4,5, Alessandra Griffa3, Timo Roine2,3,4, Yasser Alemán-Gómez2,3,4, Emeline Mullier3, Philippe Golay1, Zita Rovo2, Patric Hagmann3, Kim Q. Do2, Philippe Conus1, Pascal Steullet2, and Meritxell Bach Cuadra3,4,6

1Service of General Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 4Medical Image Analysis Laboratory (MIAL), Centre d'Imagerie BioMédicale (CIBM), Lausanne, Switzerland, 5Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 6Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

The thalamus has a central role in the pathophysiology of schizophrenia. Formed by several nuclei, it is mainly constituted by a mixture of grey and white matter and, thus, its MR signal is heavily affected by the partial volume (PV) effect. We hypothesize that tissue segmentation based on a PV model will better depict subtle changes in schizophrenia patients than total thalamus volume or local tissue volume measurements that do not consider PV. Results show statistically significant changes in gray matter and white matter average concentration from PV model within the thalamus in schizophrenia patients (SCHZ) compared to healthy controls (HC).

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