Abstract #3134

Preliminary investigation of QSM stability across sites

Renat Yakupov¹, Arturo Cardenas-Blanco^1,2, Klaus Fliessbach^3,4, Michael Wagner^3,4, Annika Spottke⁴, Stefan Teipel^5,6, Katharina Bürger^7,8, Anja Schneider^3,4, Oliver Peters^9,10, Peter Nestor¹, Josef Priller^9,10, Jens Wiltfang^11,12, Christoph Laske^13,14, Frank Jessen^3,15, Emrah Duezel^1,2,16, and Julio Acosta-Cabronero^1,17

¹German Center for Neurodegenerative Diseases, Magdeburg, Germany, ²Institute for Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany, ³Department of Psychiatry, University Hospital Bonn, Bonn, Germany, ⁴German Center for Neurodegenerative Diseases, Bonn, Germany, ⁵Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany, ⁶German Center for Neurodegenerative Diseases, Rostock, Germany, ⁷Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany, ⁸German Center for Neurodegenerative Diseases, Munich, Germany, ⁹Department of Psychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany, ¹⁰German Center for Neurodegenerative Diseases, Berlin, Germany, ¹¹Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany, ¹²German Center for Neurodegenerative Diseases, Göttingen, Germany, ¹³Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany, ¹⁴German Center for Neurodegenerative Diseases, Tübingen, Germany, ¹⁵Department of Psychiatry, University of Cologne, Cologne, Germany, ¹⁶Institute of Cognitive Neuroscience, University College London, London, United Kingdom, ¹⁷Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom

We compared quantitative susceptibility mapping (QSM) from two groups of subjects scanned at two different sites on different 3T Siemens MRI systems running different Syngo MR software versions. Qualitative whole-brain inspection of summary statistics and a statistical test comparing data from both sites revealed no major QSM offsets. The present results are only preliminary but they suggest QSM might be well suited for multi-site studies.

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