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Abstract #3134

Preliminary investigation of QSM stability across sites

Renat Yakupov1, Arturo Cardenas-Blanco1,2, Klaus Fliessbach3,4, Michael Wagner3,4, Annika Spottke4, Stefan Teipel5,6, Katharina Bürger7,8, Anja Schneider3,4, Oliver Peters9,10, Peter Nestor1, Josef Priller9,10, Jens Wiltfang11,12, Christoph Laske13,14, Frank Jessen3,15, Emrah Duezel1,2,16, and Julio Acosta-Cabronero1,17

1German Center for Neurodegenerative Diseases, Magdeburg, Germany, 2Institute for Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany, 3Department of Psychiatry, University Hospital Bonn, Bonn, Germany, 4German Center for Neurodegenerative Diseases, Bonn, Germany, 5Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany, 6German Center for Neurodegenerative Diseases, Rostock, Germany, 7Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany, 8German Center for Neurodegenerative Diseases, Munich, Germany, 9Department of Psychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany, 10German Center for Neurodegenerative Diseases, Berlin, Germany, 11Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany, 12German Center for Neurodegenerative Diseases, Göttingen, Germany, 13Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany, 14German Center for Neurodegenerative Diseases, Tübingen, Germany, 15Department of Psychiatry, University of Cologne, Cologne, Germany, 16Institute of Cognitive Neuroscience, University College London, London, United Kingdom, 17Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom

We compared quantitative susceptibility mapping (QSM) from two groups of subjects scanned at two different sites on different 3T Siemens MRI systems running different Syngo MR software versions. Qualitative whole-brain inspection of summary statistics and a statistical test comparing data from both sites revealed no major QSM offsets. The present results are only preliminary but they suggest QSM might be well suited for multi-site studies.

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