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Abstract #3135

Quantifying cortico-cerebellar structural covariance

Christopher J Steele1,2, Sejal Patel2, Jurgen Germann2, Gabriel Devenyi2, and Mallar Chakravarty2

1Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Cerebral Imaging Center, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada

Invasive tract-tracing in primates has shown that cerebellar regions (lobules) are differentially connected to the cerebral cortex. As diffusion tractography to/from the cerebellum is problematic in living humans, we propose a simple non-invasive approach to identify the patterns of grey-matter structural covariance between cerebellar lobules and the cerebral cortex as a proxy for anatomical connectivity. We performed vertex-wise linear regressions between lobular volumes and cortical thickness/surface area. We then clustered lobule-wise correlations to identify similar spatial patterns of cortico-cerebellar covariance. We identified differential patterns that may reflect the underlying connectivity between the cerebellum and cortex.

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