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Abstract #3137

Spatio-temporal features of brain's iron accumulation across the life span.

Vyacheslav Karolis1,2, Thomas Hope3, Nikolaus Weiskopf4, Martina Callaghan3, Geraint Rees5, and Marinella Cappelletti5,6

1ICM - Institut du Cerveau et de la Moelle épinière, Hôpital de la Salpêtrière, Paris, France, 2Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, 3Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom, 4Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 5Institute of Cognitive Neuroscience, University College London, London, United Kingdom, 6Psychology Department, Goldsmiths College, London, United Kingdom

In this study we characterised the spatiotemporal features of age-related iron accumulation marked by R2* maps in 97 participants distributed over the whole range of ages between 20 and 75 years old. The analyses showed a broad spectrum of linear and non-linear patterns of age-related differences in R2*. These were predominantly confined to striatum, motor, pre-motor and parietal regions of grey matter as well as subgyral pre- and postcentral regions of white matter. The spatial distribution of R2* changes seems to be related to a higher prevalence of long-distance white matter connections originating from a region.

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