Abstract #3151

APT CEST in cerebrospinal fluid in patients with multiple sclerosis at 3T

Richard Dylan Lawless^1,2, Quinn R Weinberg², Bailey Box², Samantha By³, Francesca Bagnato⁴, and Seth A Smith^1,2,5

¹Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³Phillips Healthcare, Baltimore, MD, United States, ⁴Department of Neurology, Vanderbilt University, Nashville, TN, United States, ⁵Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

There is currently no clinically available MRI method capable of monitoring chronic, systemic inflammation in the central nervous system as a confirmatory biomarker. Chemical exchange saturation transfer (CEST) is a novel MR technique sensitive to low concentration, exchangeable mobile solutes. Amide proton transfer (APT) CEST provides information about concentration of proteins/peptides with amide backbones. Our results show that APT CEST of CSF in the spinal cord demonstrates significant changes when compared between the control and MS cohort.

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