Abstract #3152

MT and QSM of the Locus Coeruleus and Substantia Nigra on human healthy subjects

Catarina Rua¹, Luca Passamonti², Claire O’Callaghan³, James Rowe^3,4,5, Adrian Carpenter¹, and Guy Williams¹

¹Department of Clinical Neurosciences, University of Cambridge, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, ²Department of Clinical Neurosciences, University of Cambridge, Cambridge Centre for Frontotemporal Dementia and related disorders, Cambridge, United Kingdom, ³University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom, ⁴University of Cambridge, Department of Clinical Neurosciences, Cambridge, United Kingdom, ⁵Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom

The Locus Coeruleus (LC) and the Substantia Nigra (SN) are located in the mid-brain are known to show severe cell loss in several neurodegenerative diseases (e.g., Alzheimer’s disease). Developing new imaging techniques to quantify the signal changes in these regions is of high clinical relevance. In this pilot study of five healthy adults from different age groups, the LC and SN were evaluated for neuromelanin and iron content with an Magnetisation Transfer-weighted sequence and with Quantitative Susceptibility Mapping, respectively.

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