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Abstract #3152

MT and QSM of the Locus Coeruleus and Substantia Nigra on human healthy subjects

Catarina Rua1, Luca Passamonti2, Claire O’Callaghan3, James Rowe3,4,5, Adrian Carpenter1, and Guy Williams1

1Department of Clinical Neurosciences, University of Cambridge, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, 2Department of Clinical Neurosciences, University of Cambridge, Cambridge Centre for Frontotemporal Dementia and related disorders, Cambridge, United Kingdom, 3University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom, 4University of Cambridge, Department of Clinical Neurosciences, Cambridge, United Kingdom, 5Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom

The Locus Coeruleus (LC) and the Substantia Nigra (SN) are located in the mid-brain are known to show severe cell loss in several neurodegenerative diseases (e.g., Alzheimer’s disease). Developing new imaging techniques to quantify the signal changes in these regions is of high clinical relevance. In this pilot study of five healthy adults from different age groups, the LC and SN were evaluated for neuromelanin and iron content with an Magnetisation Transfer-weighted sequence and with Quantitative Susceptibility Mapping, respectively.

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