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Abstract #3154

Functional MRI reveals resting state network alterations upon DREADD-induced silencing of the right dorsomedial prefrontal cortex in mice.

Lore Peeters1, Rukun Hinz1, Stephan Missault1, Marleen Verhoye1, Annemie Van der Linden1, and Georgios A. Keliris1

1Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium

Combining chemogenetics with non-invasive functional MRI (fMRI) allows establishing a link between the activity of selected populations of neurons with large-scale network activity. Here, we show that Kappa Opioid Receptor (KOR) DREADD-induced decreases in neural activity result in network alterations that can be picked up by pharmacological and resting state fMRI. In particular, inhibition of the right dorsomedial prefrontal cortex (dmPFC), a core region of the attention network in rodents, induces functional connectivity changes between other regions of the attentional network and between regions of distinct sensory networks (e.g. the visual network).

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