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Abstract #3155

Cross-Platform Comparison of Regional Brain Stiffness

Jun Chen1, Matthew Murphy1, Kevin Glaser1, Curtis Johnson2, Arvin Forghanian-Arani1, Yuan Le3, David Lake1, Roger Grimm1, John III Huston1, and Richard Ehman1

1200 1st St Sw, Mayo Clinic, Rochester, MN, United States, 2University of Delaware, Newark, DE, United States, 3200 1st St Sw, Mayo Clinic, Phoenix, AZ, United States

Brain MR Elastography (MRE) has been shown to add value to neurological imaging. Brain biomechanical properties are correlated with age, gender, exercise and memory in normal volunteers. In patients with neurological diseases, such as multiple sclerosis, dementia and intracranial tumors, global and regional brain mechanical properties may be sensitive biomarkers. Characterization of the cross-platform performance of regional stiffness measurements using 3D brain MRE is important for future multiplatform, multicenter brain MRE studies. The purpose of our study was to compare regional 3D brain MRE in normal volunteers using two vendor platforms.

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