Amide proton transfer weighted (APTw) MRI has been shown to allow assessment of the tumor aggressiveness/tumor grade with high sensitivity and specificity. Compartments with significant fluid content, like cysts, haemorrhage or necrosis may complicate reading. A metric for APTw MRI is developed, applicable for chemical exchange saturation transfer (CEST) MRI in general, which suppresses fluids based on the spectral shape of the background magnetization transfer ratio (MTR). It is shown to essentially conserve numerical values of APTw MRI in solid tissues. Furthermore, no extra acquisition time is needed, because the metric can be computed from the minimum Z-spectral data also required for standard CEST MRI. The novel metric is explored in an intial study on N=12 gliobastoma cases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords