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Abstract #3158

Optimizing Brain MR Elastography with Multiple Motion Encoding Gradient Cycles

Yuan Le1, Kevin Glaser2, Matthew Murphy2, Yuxiang Zhou3, Jun Chen2, William Pavlicek1, Joseph M. Hoxworth3, Bradley D. Bolster Jr.4, John Huston III.2, Joel P. Felmlee2, and Richard L. Ehman2

1Radiology, Mayo Clinic Arizona, Scottsdale, AZ, United States, 2Radiology, Mayo Clinic, Rochester, MN, United States, 3Radiology, Mayo Clinic Arizona, Phoenix, AZ, United States, 4Siemens Medical Solutions USA, Inc., Salt Lake City, UT, United States

A spin-echo EPI MR Elastography sequence was optimized so that multiple motion encoding gradient (MEG) cycles can be added to increase the motion sensitivity. Volunteer tests showed that comparing with the original one MEG version, optimized two or three MEG cycles provided higher Octahedral Shear Strain Signal-to-Noise Ratio (OSS-SNR), which means higher stiffness measurement precision. Global brain Images acquired with 2 and 3 MEG cycles are in most cases comparable in stiffness and OSS-SNR while images with 1 MEG tend to have a slightly lower OSS-SNR.

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