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Abstract #3159

Regional Changes in Brain Stiffness with Age Assessed with MR Elastography

Yu Sasaki1, Utaroh Motosugi1, Tomohiro Takamura2, Kevin J. Glaser3, Richard L. Ehman3, Hiroshi Kumagai1, Takashi Kakegawa1, and Hiroshi Onishi1

1Department of Radiology, University of Yamanashi, Yamanashi, Japan, 2Department of Radiology, Juntendo University, Tokyo, Japan, 3Department of Radiology, Mayo Clinic, Rochester, MN, United States

Various MR-assessed quantities change with age in the brain, including T2, diffusion, and fractional anisotropy. MR elastography (MRE) is a new technique that can measure the stiffness of tissue and is now widely used in the clinic for assessing hepatic fibrosis. Recently, it has become feasible to perform brain MRE as well. In this study, we showed that the stiffness of the brain, measured using MRE, decreased with age, especially in the parietal lobes and the sensory-motor area.

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