Abstract #3159

Regional Changes in Brain Stiffness with Age Assessed with MR Elastography

Yu Sasaki¹, Utaroh Motosugi¹, Tomohiro Takamura², Kevin J. Glaser³, Richard L. Ehman³, Hiroshi Kumagai¹, Takashi Kakegawa¹, and Hiroshi Onishi¹

¹Department of Radiology, University of Yamanashi, Yamanashi, Japan, ²Department of Radiology, Juntendo University, Tokyo, Japan, ³Department of Radiology, Mayo Clinic, Rochester, MN, United States

Various MR-assessed quantities change with age in the brain, including T2, diffusion, and fractional anisotropy. MR elastography (MRE) is a new technique that can measure the stiffness of tissue and is now widely used in the clinic for assessing hepatic fibrosis. Recently, it has become feasible to perform brain MRE as well. In this study, we showed that the stiffness of the brain, measured using MRE, decreased with age, especially in the parietal lobes and the sensory-motor area.

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