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Abstract #3166

Imaging toxin-induced inflammation in the mouse brain with hyperpolarized 13C MRS

Lydia M Le Page1,2, Caroline Guglielmetti1,2, Brice Tiret1,2, and Myriam M Chaumeil1,2

1Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, 2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

13C MRS of hyperpolarized (HP) [1-13C] pyruvate has recently shown promise in assessing neuroinflammation in mouse models of MS and TBI. Here, we expanded on previous reports and evaluated whether HP 13C MRS could detect the effect of the inflammation-inducing toxin lipopolysaccharide (LPS), using mice injected intracranially with either LPS or saline. LPS-injected mice showed significantly elevated HP [1-13C] lactate:pyruvate ratios in the LPS-injected hemisphere compared to contralateral, in line with increased microglial number. In contrast, saline-injected mice showed no such changes. Our results further confirm the potential of hyperpolarized 13C MRS for non-invasive assessment of neuroinflammation in the brain.

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