Abstract #3168

19F Signal Distribution in Pre-Symptomatic Experimental Autoimmune Encephalomyelitis

Paula Ramos Delgado¹, Jason M. Millward¹, Christian Prinz¹, Ludger Starke¹, Stefanie Münchberg¹, Andreas Pohlmann¹, Thoralf Niendorf^1,2, and Sonia Waiczies¹

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association(MDC), Berlin, Germany, Berlin, Germany, ²Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Berlin, Germany

Experimental autoimmune encephalomyelitis (EAE) is an animal model used to study the pathogenesis of autoimmune neuroinflammatory diseases, such as multiple sclerosis (MS). In MS, recruitment of immune cells into the central nervous system (CNS) occurs already at early stages of the disease. Magnetic resonance imaging (MRI) can be used as a non-invasive technique suited for tracking immune cell migration, following intravenous administration of fluorine (¹⁹F)-loaded nanoparticles which can then be followed using ¹⁹F MR techniques. The present study aims to investigate the distribution of immune cells during the pre-symptomatic disease phase in the EAE mouse model using ¹⁹F MR methods.

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