Cerebral small vessel disease (SVD) is the major cause of dementia among the elderly and sensitive biomarkers of disease progression are needed. Here, we investigated the potential of DWI to provide sensitive biomarkers of SVD, by evaluation multiple metrics extracted from DTI in terms of their predictive power of cognitive performance. We considered different white matter regions of interest to perform histogram analysis and extract multiple FA and MD metrics, and showed that specific DTI metrics were better than conventional structural MRI at explaining impairments in processing speed and execute function in a group of SVD patients.
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