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Abstract #3174

Systematic comparison of DTI metrics as potential biomarkers  in cerebral small vessel disease

Ana Fouto1, Rita G. Nunes1, Joana Pinto1, Luísa Alves2, Sofia Calado2, Carina Gonçalves2, Pedro Vilela3, Miguel Viana Baptista2, and Patrícia Figueiredo1

1Department of Bioengineering, ISR-Lisboa/LARSyS, Instituto Superior Técnico - Universidade de Lisboa, Lisboa, Portugal, 2Department of Neurology, Hospital Egas Moniz, Lisbon, Portugal, 3Imaging Department, Hospital da Luz, Lisbon, Portugal

Cerebral small vessel disease (SVD) is the major cause of dementia among the elderly and sensitive biomarkers of disease progression are needed. Here, we investigated the potential of DWI to provide sensitive biomarkers of SVD, by evaluation multiple metrics extracted from DTI in terms of their predictive power of cognitive performance. We considered different white matter regions of interest to perform histogram analysis and extract multiple FA and MD metrics, and showed that specific DTI metrics were better than conventional structural MRI at explaining impairments in processing speed and execute function in a group of SVD patients.

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