Single post-labeling-delay (PLD) pCASL are commonly used to measure cerebral blood flow (CBF). A PLD of 1500-2000ms is commonly used in children and adults. Multi-delay pCASL has been developed as an alternative approach to better account for prolonged arterial transit times (ATT) and to improve the accuracy of CBF perfusion quantification. In this study, we evaluate the feasibility of multi-delay pCASL in children. We compare two algorithms (weighted-delay linear mapping vs. nonlinear iterative curve fitting) for estimating ATT and CBF. We further compare estimations of weighted-delay CBF derived from multi-delay pCASL data with those traditionally calculated from a single PLD measurement.
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