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Abstract #3179

$$$T_1$$$ dependency of magnetization transfer effect in human brain

Yuki Kanazawa1, Toshiaki Sasaki2, Hiroaki Hayashi1, Kotaro Baba3, Ikuho Kosaka3, Yuki Matsumoto4, Mitsuharu Miyoshi5, and Masafumi Harada1

1Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, 2Department of Radiology, Uji Tokushukai Hospital, Uji, Japan, 3School of Health Sciences, Tokushima University, Tokushima, Japan, 4Graduate school of Health Science, Tokushima University, Tokushima, Japan, 5Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan

The purpose of this study is to develop a T1 mapping method derived from the variable flip angle with an MT pulse. T1 mapping of the brain with an MT pulse was performed in five healthy subjects. The mean T1_MT values were significantly decrease than the T1 in all regions (P < 0.05). The difference of T1 and T1_MT in deep gray matter (included caudate nucleus and putamen) were more decreased than those in white matter. In conclusion, determination of T1 with MT pulse makes it possible to obtain more detailed information of the macromolecular pool and the free water pool.

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