Abstract #3179

$$$T_1$$$ dependency of magnetization transfer effect in human brain

Yuki Kanazawa¹, Toshiaki Sasaki², Hiroaki Hayashi¹, Kotaro Baba³, Ikuho Kosaka³, Yuki Matsumoto⁴, Mitsuharu Miyoshi⁵, and Masafumi Harada¹

¹Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, ²Department of Radiology, Uji Tokushukai Hospital, Uji, Japan, ³School of Health Sciences, Tokushima University, Tokushima, Japan, ⁴Graduate school of Health Science, Tokushima University, Tokushima, Japan, ⁵Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan

The purpose of this study is to develop a T₁ mapping method derived from the variable flip angle with an MT pulse. T₁ mapping of the brain with an MT pulse was performed in five healthy subjects. The mean T_{1_MT} values were significantly decrease than the T₁ in all regions (P < 0.05). The difference of T₁ and T_{1_MT} in deep gray matter (included caudate nucleus and putamen) were more decreased than those in white matter. In conclusion, determination of T₁ with MT pulse makes it possible to obtain more detailed information of the macromolecular pool and the free water pool.

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