Abstract #3197

IVIM DWI in the assessment of renal diffusion and perfusion alternations in ischemic acute kidney injury (AKI) animals

Chengyan Wang^1,2, Hanjing Kong², Fei Gao³, Li Jiang⁴, Jue Zhang^2,3, and Xiaoying Wang^2,5

¹Institute for Medical Imaging Technology, Shanghai Jiao Tong university, Shanghai, China, ²Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, ³College of Engineering, Peking University, Beijing, China, ⁴Philips Healthcare, Suzhou, China, ⁵Department of Radiology, Peking University First Hospital, Beijing, China

Intravoxel incoherent motion (IVIM) DWI is able to simultaneously detect diffusion and perfusion characteristics of renal tissue, which provides more sensitive measurement of renal function than serum creatinine. This study investigates the feasibility of using IVIM DWI to evaluate renal diffusion and perfusion changes in ischemic AKI animals. IVIM DWI was performed on rabbits prior to (24 hours before surgery) and after the surgery (1 hour, 3 hours, 1 week and 2 weeks after surgery). After injection of 0.8 mg microspheres, a noticeable change of renal diffusion and perfusion can be seen in the cortex immediately after the surgery. Pathological results also confirmed the renal injury with findings of ischemic and wrinkled features with dilated change of Bowman’s capsule.

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