Meeting Banner
Abstract #3209

Evaluation of two collagen conduits and autograft in sciatic nerve regeneration in a rabbit nerve gap model with DTI, histology and electrophysiology

Tina Jeon1, Emil S Vutescu2, Eliana B Saltzman2, Jordan C Villa2, Scott W Wolfe2, Steve K Lee2, Joseph H Feinberg3, Sarah L Pownder1, Jonathan P Dyke4, and Darryl B Sneag1

1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Department of Hand and Upper Extremity Service, Hospital for Special Surgery, New York, NY, United States, 3Department of Rehabilitation Medicine, Hospital for Special Surgery, New York, NY, United States, 4Citigroup Biomedical Imaging Center, Weill Cornell Medical College, New York, NY, United States

DTI has been used primarily to evaluate white matter tracks in the brain. More recent studies have applied DTI techniques to peripheral nerves, due to their anisotropic architecture. In this investigation, we evaluated peripheral nerve regeneration in a rabbit sciatic nerve gap model comparing two collagen conduits with nerve autograft using DTI and comparison with functional/physiologic testing and histology. We hypothesized that this study would allow us to reliably compare outcomes of nerve regeneration between collagen-based conduits and autograft nerve reconstructions and provide validation for the use of DTI techniques to non-invasively monitor nerve regeneration in-vivo.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords