The purpose of this study was to assess the role of readout segmentation of long variable echo-trains(RESOLVE) DWI in differentiating benign and malignant lesions of the tongue. 120 patients with lingual lesions underwent preoperative RESOLVE DWI. The results demonstrated that the mean ADC values of benign lesions of the tongue were significantly higher than malignant lesions. Using an ADC value of 1.25×10-3 mm2/s as the threshold value, the sensitivity and specificity were 94.64%, 93.75% respectively. RESOLVE can offer high quality DWI of tongue. The ADC value can be applied in differential diagnosis between benign and malignant lesions of the tongue
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