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Abstract #3216

Diffusion kurtosis imaging in evaluating non-Hodgkin’s lymphoma: associations with tumor aggressiveness and proliferation

Jing Zhong1, Yunbin Chen1, Ying Chen1, Cuifang Chen1, and Weibo Chen2

1Radiology, Fujian Cancer Hospital, Fuzhou, China, 2Philips Healthcare, Shanghai, China

This study tries to evaluate the usefulness of diffusion kurtosis imaging (DKI) parameters in segregating the pathological subtypes of NHL lymphoma, and to explore its associations with aggressiveness and proliferative index. Significant differences were found among the WHO classified subgroups. Meanwhile, the stronger tumor aggressiveness (higher Ki67 percentage) was accompanied with more restricted water diffusivity (lower ADC and D values) and more complex cell micro-structural environment (higher K value). The DKI technique may help estimation of tumor proliferation in NHL lymphoma and DKI parameters can be used as imaging biomarker of the biological aggressiveness of the tumor.

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