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Abstract #3217

Assessment of the Specificity and Sensitivity of DTI Metrics for Evaluation and Diagnosis in Degenerative Cervical Myelopathy

Guangqi Li1, Xiaodong Ma1, JinChao Wang2, Donghang Li2, Xiao Han2, Wen Jiang3, Xiaoguang Cheng3, and Hua Guo1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing, China, 3Department of Radiology, Beijing Jishuitan Hospital, Beijing, China

Diffusion Tensor Imaging (DTI) can detect diffusion information of water molecules, and is used to diagnose the severity of degenerative cervical myelopathy (DCM). However, the diagnostic capability of DTI metrics is not fully investigated. In this study, DTI metrics are employed to evaluate the spinal cord function in preoperative DCM patients and healthy volunteers. Nonparametric t-test results show that MD, FA and RD have significant differences between patients and healthy volunteers. In addition, ROC results indicate that FA has higher sensitivity, RD has higher specificity for evaluation and diagnosis in DCM.

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