Despite the growing research in free water elimination (FWE) methods with advanced diffusion acquisition protocols, the need for robust single-shell based FWE remains, as this is the standard acquisition protocol in the clinic. This is especially important in the characterization of peritumoral regions with infiltration. However, single-shell FWE is an ill-posed problem, dependent on parameter initialization, solutions to which often fail to obtain a balanced correction between healthy and abnormal tissue. We introduce FERNET, a robust FWE protocol for single-shell data with a comprehensive investigation of initialization parameters based on a software simulated phantom where the ground truth is known.
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