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Abstract #3229

Free watER iNvariant Estimation of Tensor (FERNET): Addressing the Issue of Edema in Clinically Feasible Acquisitions

Abdol Aziz Ould Ismail1, Drew Parker1, Simon Alexander2, Emmanuel Caruyer3, Ofer Pasternak4, and Ragini Verma1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Synaptive Medical Inc., Toronto, ON, Canada, 3IRISA, CNRS, Rennes, France, 4Psychiatry and Radiology, Harvard Medical School, Boston, MA, United States

Despite the growing research in free water elimination (FWE) methods with advanced diffusion acquisition protocols, the need for robust single-shell based FWE remains, as this is the standard acquisition protocol in the clinic. This is especially important in the characterization of peritumoral regions with infiltration. However, single-shell FWE is an ill-posed problem, dependent on parameter initialization, solutions to which often fail to obtain a balanced correction between healthy and abnormal tissue. We introduce FERNET, a robust FWE protocol for single-shell data with a comprehensive investigation of initialization parameters based on a software simulated phantom where the ground truth is known.

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