We show that multi-shell (multi b-value), multi-directional, and high spatial resolution (300 microns isotropic) diffusion MRI combined with multi-tissue fiber orientation distribution function (fODF) tractography increases by 6% the number of true positive connections and uniformly increases the cortical coverage by 3%, while preserving the same percentage of false positive connections, with respect to a more standard single-tissue single-shell tractography. As a result, it is possible to find all 5 ground truth V1-V2 bundles (true positives), while reconstructing only 4 invalid bundles (false positives) corresponding to 4 pairs of spatially neighboring regions.
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