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Abstract #3230

Multi-shell multi-tissue fODF tractography improves V1-V2 macaque connectivity mapping

Guillaume Theaud1, Maxime Descoteaux1, Rémi Cossette-Roberge1, Jean-Christophe Houde1, Chuyang Ye2, Nathalie Richard3, Yujie Hou4, Loïc Magrou4, Kenneth Knoblauch4, Henry Kennedy4, and Bassem Hiba3

1Sherbrooke Connectivity Imaging Lab (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada, 2Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Institut des Sciences Cognitives Marc Jeannerod, CNRS/université Lyon1 (UMR 5229), Bron, France, 4Inserm, Stem Cell and Brain Research Institute U1208, Université Claude Bernard Lyon 1, Bron, France

We show that multi-shell (multi b-value), multi-directional, and high spatial resolution (300 microns isotropic) diffusion MRI combined with multi-tissue fiber orientation distribution function (fODF) tractography increases by 6% the number of true positive connections and uniformly increases the cortical coverage by 3%, while preserving the same percentage of false positive connections, with respect to a more standard single-tissue single-shell tractography. As a result, it is possible to find all 5 ground truth V1-V2 bundles (true positives), while reconstructing only 4 invalid bundles (false positives) corresponding to 4 pairs of spatially neighboring regions.

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