Abstract #3243

Brain morphometry using diffusion MRI data (DTBM) reveals abnormalities in Down Syndrome that are not detected by conventional DTI analysis.

Carlo Pierpaoli¹, Amritha Nayak¹, Okan Irfanoglu¹, Neda Sadeghi¹, and Nancy Raitano-Lee²

¹Quantitative Medical Imaging Section, NIBIB, NIH, Bethesda, MD, United States, ²Department of Psychology, Drexel University, Philadelphia, PA, PA, United States

We performed Tensor Brain Morphometry (TBM) as well as conventional FA analysis to compare the brains of subjects with Down Syndrome (DS) to typically developing Healthy Controls (HC). TBM deformation fields were computed from T1 weighted images (T1-TBM), as well as from diffusion data (D-TBM). D-TBM identifies differences between DS and HC brains that would have gone completely undetected by conventional TBSS analysis of FA results.

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