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Abstract #3243

Brain morphometry using diffusion MRI data (DTBM) reveals abnormalities in Down Syndrome that are not detected by conventional DTI analysis.

Carlo Pierpaoli1, Amritha Nayak1, Okan Irfanoglu1, Neda Sadeghi1, and Nancy Raitano-Lee2

1Quantitative Medical Imaging Section, NIBIB, NIH, Bethesda, MD, United States, 2Department of Psychology, Drexel University, Philadelphia, PA, PA, United States

We performed Tensor Brain Morphometry (TBM) as well as conventional FA analysis to compare the brains of subjects with Down Syndrome (DS) to typically developing Healthy Controls (HC). TBM deformation fields were computed from T1 weighted images (T1-TBM), as well as from diffusion data (D-TBM). D-TBM identifies differences between DS and HC brains that would have gone completely undetected by conventional TBSS analysis of FA results.

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