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Abstract #3272

Altered Topological Properties of Brain Functional Networks in Type I GD Patients During a Near Five-year Follow-up

Di Hu1, Miao Zhang1, Shengpei Wang2, Huiying Kang1, and Yun Peng1

1Beijing Children's Hospital, Capital Medical University,National Center for Children's Health, China, Beijing, China, 2State Key Laboratory of Management and Control for ComplexSystems, Institute of Automation, Chinese Academy of Sciences, Beijing, China, Beijing, China

Our previous had shown altered nodal properties within the executive control network in children with type I GD. This time we further investigate the variation trend of brain topological properties in type I GD patients during a near five-year folloe-up under regular enzyme replacement. Results showed that the efficiency of functional segregation in brain network were increased and more nodes were involved and reorganized. The result may explain the improved mood and global functioning that have previous reported.

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