Abstract #3273

Multimodal study of hyperbaric oxygenation effects on normal human brain metabolism and functional connectivity at 3 Tesla.

Andrei Valerievich Manzhurtsev^1,2, Olga Vasiukova³, Dmitry Kupriyanov⁴, Victoria Sergeeva⁵, Tolib Akhadov², Petr Menshchikov^2,6, and Natalia Semenova^1,2,6

¹0501, Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation, ²Radiology, Clinical and Research Institute of Emergent Pediatric Surgery and Trauma, Moscow, Russian Federation, ³National Research Nuclear University MEPhI, Moscow, Russian Federation, ⁴Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation, ⁵Hyperbaric Oxygen Dept., Clinical and Research Institute of Emergent Pediatric Surgery and Trauma, Moscow, Russian Federation, ⁶Semenov Institute of Chemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation

This study is aimed to reveal the effects of hyperbaric oxygenation (HBO) on human brain metabolites using ¹H and ³¹P MRS, and functional connectivity using resting-state fMRI. The MRS and rs-fMRI studies were performed twice: before and after one HBO session (p=1.2 atmosphere, 100% O₂). The results demonstrate the positive effect of hyperbaric oxygenation on human brain metabolism and functioning.

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