Abstract #3280

Temporal evolution of functional connectivity of the intrinsic networks in mild traumatic brain injury

Zhuonan Wang¹, Lijun Bai², Qiuli Zhang¹, Guanghui Bai³, Bo Yin⁴, Xuan Niu¹, Yingxiang Sun¹, and Ming Zhang¹

¹Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, XI AN, China, ²The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’ an Jiaotong University, XIAN, China, ³Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, ⁴Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China

Mild traumatic brain injury (mTBI) often leads to disconnection of the brain intrinsic networks. Our study was to investigate how SN interacts with CEN/DMN can be viewed from the observation of how network connectivity damage affects other networks as a function of time, as well as its impact on cognition and emotion. The results suggests that intrinsic brain networks in mTBI patients showed continued damage from acute to sub-acute phase after injury. Function connectivity of SN interacts with CEN/DMN are especially susceptible in mTBI patients and the damage for inter-network functional disconnection will lead to high level cognitive dysfunction.

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