Abstract #3281

A preliminary report: Confirmation of the relationship of episodic memory performance and frontoparietal functional connectivity in Multiple Sclerosis

Katherine A Koenig¹, Jian Lin¹, Daniel Ontaneda², Kedar Mahajan², Stephen M Rao³, Sanghoon Kim¹, Stephen Jones¹, and Mark J Lowe¹

¹Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, ²Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, ³Schey Center for Cognitive Neuroimaging, The Cleveland Clinic, Cleveland, OH, United States

This work assesses the relationship of resting state fMRI (rs-fMRI) of the dorsal lateral prefrontal cortex to episodic memory in patients with multiple sclerosis (MS). We find that rs-fMRI in the frontoparietal network is related to performance on a verbal episodic memory measure. This finding confirms previous reports and suggests this measure is appropriate to investigate as a potential predictive marker of cognitive decline.

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