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Abstract #3281

A preliminary report: Confirmation of the relationship of episodic memory performance and frontoparietal functional connectivity in Multiple Sclerosis

Katherine A Koenig1, Jian Lin1, Daniel Ontaneda2, Kedar Mahajan2, Stephen M Rao3, Sanghoon Kim1, Stephen Jones1, and Mark J Lowe1

1Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, 2Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, 3Schey Center for Cognitive Neuroimaging, The Cleveland Clinic, Cleveland, OH, United States

This work assesses the relationship of resting state fMRI (rs-fMRI) of the dorsal lateral prefrontal cortex to episodic memory in patients with multiple sclerosis (MS). We find that rs-fMRI in the frontoparietal network is related to performance on a verbal episodic memory measure. This finding confirms previous reports and suggests this measure is appropriate to investigate as a potential predictive marker of cognitive decline.

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