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Abstract #3282

Diffusion MR Imaging of Structural Connectivity and Therapeutic Potential of Deep Brain Stimulation in Alzheimer’s Disease Model

Ching-Wen Chang1, Yi-Chao Lee2, Ssu-Ju Li1, Ting-Chun Lin1, Yin-Chieh Liu1, You-Yin Chen1, and Yu-Chun Lo2

1Biomedical Engineering, National Yang Ming University, Taipei, Taiwan, 2The Ph.D. Program for Neural Regenerative Medicine, Taipei Medical Univeristy, Taipei, Taiwan

Alzheimer’s disease (AD) is one of the major causes of death that currently cannot be reversed or slowed. Fornix, a major output tract of the hippocampus, has been shown to be a promising target for DBS therapy in AD patients. In this study, triple-transgenic Alzheimer’s mice were used to investigate the changes of white matter integrity and the cognitive functions after the DBS-fornix therapy. We found improvement of the cognition and increased white matter integrity after that DBS-fornix therapy in AD mice. It suggested that the DBS-fornix therapy may be a potential therapeutic intervention of AD.

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