Abstract #3283

Modulation of cortico-subcortical functional connectivity occurs after symptomatic treatment of fatigue in patients with multiple sclerosis

Paola Valsasina¹, Bruno Colombo², Paolo Preziosa^1,2, Vittorio Martinelli², Andrea Falini³, Giancarlo Comi², Massimo Filippi^1,2, and Maria A. Rocca^1,2

¹Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ³Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

In this study, 45 fatigued patients with multiple sclerosis (MS) were randomly assigned to undergo treatment with fampridine, amantadine or placebo and underwent clinical, neuropsychological and 3T resting state (RS) functional MRI at baseline and after four weeks of treatment. We found that treatment with fampridine (and, to a lesser extent, with amantadine) ameliorates fatigue in MS. Concomitant increase of RS functional connectivity (FC) in inferior frontal and parietal cortical regions, and decrease of abnormally high intra-thalamic FC were detected, suggesting an improved regulation of cortico-subcortical functional circuits.

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