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Abstract #3284

Relevance of functional connectivity abnormalities to cognitive impairment in neuromyelitis optica spectrum disoders

Paola Valsasina1, Maria A. Rocca1,2, Filippo Savoldi1, Gianna Carla Riccitelli1, Marta Radaelli2, Paolo Preziosa1,2, Giancarlo Comi2, Andrea Falini3, and Massimo Filippi1,2

1Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 3Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

In this study, we explored resting state (RS) functional connectivity (FC) abnormalities of the main cognitive networks of patients with neuromyelitis optica spectrum disorders (NMOSD) and their correlation with cognitive impairment (CI). We found increased RS FC in the default mode, salience and working memory networks in cognitively preserved NMOSD, and decreased RS FC in the default mode and working memory networks in CI NMOSD. Increased RS FC seems to contribute to a better cognitive performance, probably reflecting an adaptive mechanism. Conversely, reduced RS FC is likely to be a maladaptive mechanism associated with impaired cognitive functions.

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