Abstract #3285

Longitudinal Evaluation of Post-Surgical Connectivity Changes of the Default Mode Network in Operated Glioma Patients

Domenico Zacà¹, Silvio Sarubbo², Monica Dalla Bona², Umberto Rozzanigo³, Francesco Corsini², Giovanna Faraca², Franco Chioffi², and Jorge Jovicich¹

¹Center for Mind/Brain Sciences-University of Trento, Trento, Italy, ²Department of Neurosciences, Division of Neurosurgery, “S. Chiara” Hospital, Trento APSS, Trento, Italy, ³Department of Radiology, “S. Chiara” Hospital, Trento APSS, Trento, Italy

In this study we evaluated the post-surgical changes in functional connectivity of the default mode network (DMN) in 6 operated glioma patients and assessed their relationship with pre-operative brain tumor size, a factor that pre-operatively has been negatively associated to cognitive performance. We found in all but one patient an increase in connectivity (average Z-score) of the DMN following brain tumor surgery. These changes were not associated with brain tumor volume, thus indicating that mechanisms other than reduction of mass effect may drive the post-surgical reorganization of the DMN.

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