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Abstract #3285

Longitudinal Evaluation of Post-Surgical Connectivity Changes of the Default Mode Network in Operated Glioma Patients

Domenico Zacà1, Silvio Sarubbo2, Monica Dalla Bona2, Umberto Rozzanigo3, Francesco Corsini2, Giovanna Faraca2, Franco Chioffi2, and Jorge Jovicich1

1Center for Mind/Brain Sciences-University of Trento, Trento, Italy, 2Department of Neurosciences, Division of Neurosurgery, “S. Chiara” Hospital, Trento APSS, Trento, Italy, 3Department of Radiology, “S. Chiara” Hospital, Trento APSS, Trento, Italy

In this study we evaluated the post-surgical changes in functional connectivity of the default mode network (DMN) in 6 operated glioma patients and assessed their relationship with pre-operative brain tumor size, a factor that pre-operatively has been negatively associated to cognitive performance. We found in all but one patient an increase in connectivity (average Z-score) of the DMN following brain tumor surgery. These changes were not associated with brain tumor volume, thus indicating that mechanisms other than reduction of mass effect may drive the post-surgical reorganization of the DMN.

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