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Abstract #3291

Age-related changes in cortical thickness and R1 values measured at 7T

Koji Fujimoto1, Yuta Urushibata2, Hideto Kuribayashi2, Tobias Kober3,4,5, Tadashi Isa1, and Tomohisa Okada1

1Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Siemens Healthcare K.K., Tokyo, Japan, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 5Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Healthy volunteers at the age between 20-30 (N=22) and over 60 (N=8) were scanned using a 7T MRI and a 1ch-Tx/32ch-Rx coil with a MP2RAGE prototype sequence at 0.7mm isotropic resolution. Cerebral cortex was segmented based on the human connectome project pipelines with some modifications to obtain cortical thickness and R1 on the gray-ordinate space. Results showed that the average cortical thickness decreased from 2.58 to 2.34 (9%) between the age groups; average R1 increased from 0.542 to 0.552 (1.9%). R1 change seems to have spatial predominance, with the preference in the frontal area.

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