Abstract #3291

Age-related changes in cortical thickness and R1 values measured at 7T

Koji Fujimoto¹, Yuta Urushibata², Hideto Kuribayashi², Tobias Kober^3,4,5, Tadashi Isa¹, and Tomohisa Okada¹

¹Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Siemens Healthcare K.K., Tokyo, Japan, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁵Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Healthy volunteers at the age between 20-30 (N=22) and over 60 (N=8) were scanned using a 7T MRI and a 1ch-Tx/32ch-Rx coil with a MP2RAGE prototype sequence at 0.7mm isotropic resolution. Cerebral cortex was segmented based on the human connectome project pipelines with some modifications to obtain cortical thickness and R1 on the gray-ordinate space. Results showed that the average cortical thickness decreased from 2.58 to 2.34 (9%) between the age groups; average R1 increased from 0.542 to 0.552 (1.9%). R1 change seems to have spatial predominance, with the preference in the frontal area.

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