Abstract #3297

Dissecting white-matter fiber pathways of the marmoset brain using ultra-high-resolution diffusion MRI at 7T and 14T

Cirong Liu¹, John Newman², Cecil Chern-Chyi Yen¹, Frank Ye³, David Leopold³, and Afonso C. Silva¹

¹National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ²The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ³National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

The common marmoset has received growing interests in neuroscience. The lissencephalic brain of the marmoset grants it experimental advantages for brain mapping and stimulation, but also brings challenges for dissecting white matter tracts, which is poorly depicted in existing marmoset brain atlases. Here, we collected ultra-high-resolution diffusion MRI datasets at 7T and 14T and performed probabilistic tractography and manual segmentation. The marmoset brain demonstrates a complex multi-layer white matter structure with many regions consist of multiple different fiber pathways. With the ultra-high-resolution data, we will provide the first comprehensive map (atlas) for the white matter of the marmoset brain.

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