Abstract #3298

Age-related neurochemical changes in normal human brain: a proton MR spectroscopy study at 7T

Toru Ishii¹, Koji Fujimoto¹, Hideto Kuribayashi², Yuta Urushibata², Nouha Salibi³, Ravi Teja Seethamraju³, Sinyeob Ahn³, Tadashi Isa¹, and Tomohisa Okada¹

¹Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Siemens Healthcare K.K., Japan, Tokyo, Japan, ³Siemens Healthcare, Charlestown, MA, United States

The purpose of this study was to quantify changes of neurochemical concentrations in human brain associated with normal aging with greater sensitivity and accuracy using ultra-high field 7T-MRI. 1H magnetic resonance spectra in the posterior cingulate cortex of 54 healthy adults were measured using a stimulated echo acquisition mode (STEAM) sequence with short echo time, and analysed with LCModel. In addition to the expected result of NAA decrease with aging, both Glutamate and GABA showed significant negative correlations with age. The results may provide significant insights in understanding alterations of human brain accompanying the normal aging.

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