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Abstract #3298

Age-related neurochemical changes in normal human brain: a proton MR spectroscopy study at 7T

Toru Ishii1, Koji Fujimoto1, Hideto Kuribayashi2, Yuta Urushibata2, Nouha Salibi3, Ravi Teja Seethamraju3, Sinyeob Ahn3, Tadashi Isa1, and Tomohisa Okada1

1Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Siemens Healthcare K.K., Japan, Tokyo, Japan, 3Siemens Healthcare, Charlestown, MA, United States

The purpose of this study was to quantify changes of neurochemical concentrations in human brain associated with normal aging with greater sensitivity and accuracy using ultra-high field 7T-MRI. 1H magnetic resonance spectra in the posterior cingulate cortex of 54 healthy adults were measured using a stimulated echo acquisition mode (STEAM) sequence with short echo time, and analysed with LCModel. In addition to the expected result of NAA decrease with aging, both Glutamate and GABA showed significant negative correlations with age. The results may provide significant insights in understanding alterations of human brain accompanying the normal aging.

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