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Abstract #3301

Localizing nociresponsive region within area 3a in human cortex using fMRI at 7T

Rosa M Sanchez Panchuelo1, Sally Eldeghaidy1, Francis McGlone2, Oleg Favorov3, and Susan Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Liverpool John Moores University, Liverpool, United Kingdom, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

A component of Brodmann area 3a has been shown to be highly responsive to thermonoxious skin stimulation in monkey studies. Here, we use BOLD fMRI at 7T to map on a fine scale the functional representation of a noxious heat stimulus in human primary somatosensory cortex (S1), and compare this to the hand representation identified from vibrotactile stimulation. Thermonoxious stimulation of both the palm and digits evoked a spatially distinct activation within S1, which extends beyond and partially overlaps with the anterior area responding to vibrotactile activation, consistent with the location of nociresponsive area 3a in monkeys.

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