There is enormous benefit for non-invasive MRI techniques guiding neurosurgeons to resect tissue causing epilepsy. We extend traditional EEG-fMRI methods in 3 ways: apply 7T to increase BOLD signal; use increased temporal resolution (TR 300ms) from multiband techniques to separate primary from secondary epileptogenic zones; and use paradigm-free mapping to identify interictal spikes obtained during long scans. We test this methodology using isolated finger taps as a surrogate for epileptogenic spikes. Close correspondence between conventional event analysis and paradigm free mapping suggests epileptogenic spikes can be reliably detected if their HRF is similar to a single finger tap.
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