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Abstract #3307

In vivo characterization of cerebellar microglia activation in multiple sclerosis by combined 11C-PBR28 MR-PET and 7 Tesla MRI.

Valeria Teresa Barletta1,2, Elena Herranz1,2, Constantina Andrada Treaba1,2, Russell Ouellette1, Marco Loggia1,2, Ambica Mehndiratta1, Eric Klawiter2,3, Jacob Sloane2,4, and Caterina Mainero1,2

1Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Neurology, Massachusetts General Hospital, Boston, MA, United States, 4Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States

We assessed microglia activation in the cerebellum and its relationship to clinical parameters in 27 subjects with multiple sclerosis (MS) and 18 healthy controls by using integrated 3 Tesla magnetic resonance-positron emission tomography imaging with 11C-PBR28.

The MS cohort showed increased cerebellar microglia activation in both lesioned and normal appearing cerebellum. The highest microglia activation was found in lesions, mainly concentrated in the cerebellar white matter in relapsing remitting patients, and extensively involving the cortical grey matter in progressive patients. In MS, the tracer uptake in the cerebellar white matter correlated with neurological disability and impaired cognitive performance.

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