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Abstract #3308

Comparison between 3D white-matter-suppressed MPRAGE and 3D SPACE FLAIR in the 7T MR imaging of tuberous sclerosis complex

Kaibao Sun1,2, Jianfei Cui3, Bo Wang1, Zhongwei Chen1, Yan Zhuo1,2, Rong Xue1,2, Shuli Liang3, and Lin Chen1,2

1State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Chinese PLA general hospital, Beijing, China

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder, which was characterized by tubers at the interface of gray and white matters. The 3D SPACE FLAIR sequence has previously been applied to detect the TSC lesions at 7T. The major limitations are its insensitivity to subtle lesions and long acquisition time. 3D white matter suppressed (WMS) MPRAGE was proposed in this study. T1-weighted 3D WMS MPRAGE suppressed the normal white matter signal selectively and made the lesions stand out. In comparison with 3D SPACE FLAIR, 3D WMS MPRAGE could detect more subtle tubers and details within reasonable time.

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