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Abstract #3310

MRI of whole brain formalin-fixed samples at 9.4T: influence of the fixation agent and its dielectric properties on image quality

Gisela E Hagberg1,2, Thomas Shiozawa-Bayer3, Christian Mirkes2, Jörn Engelmann2, Jonas Bause2, Bernhard Hirt3, and Klaus Scheffler1,2

1Biomedical Magnetic Resonnce, University Hospital Tübingen, Tübingen, Germany, 2High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Institute of Clinical Anatomy, University Hospital Tübingen, Tübingen, Germany

MRI of post mortem samples in formalin is an essential tool for validation purposes and comparison with clinical histology, since fixation preserve several microstructural tissue features. We found that the dielectric properties of the fixative influences image quality attained in whole brain post mortem samples at 9.4T. The standard fixative prevented high quality MRI across the entire sample. By using a high conductivity fixative with less field focussing, a more homogeneous excitation was achieved without any drop outs and T1 mapping could be performed using rapid inversion recovery techniques.

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