The gray mouse lemur (Microcebus murinus) is a small non-human primate with rapid maturity. This study focuses on the development of non-invasive MRI tools applied to neurodegenerative processes. We performed three different types of analysis: anatomical volumetric measures, neuronal network assessment with resting-state fMRI and brain glutamate distribution with gluCEST imaging. We found anatomical atrophy and functional deficiency mostly in cortical regions. To our knowledge, this study is the first to characterize the functional and anatomical brain aging process in a non-human primate. Furthermore, the mouse lemur functional and gluCEST maps have never been described before.
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