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Abstract #3313

Resting state, gluCEST and anatomical MRI approaches at 11.7T for brain aging studies in a non-human primate

Clément Garin1, Nachiket Abhay Nadkarni1, Salma Bougacha1,2, Jeremy Pepin1, Julien Flament1, Jean-Luc Picq1,3, and Marc Dhenain1

1Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Fontenay-aux-Roses, France, Fontenay aux roses, France, 23U1077, INSERM, Caen, France, 3Laboratoire de psychopathologie et de neuropsychologie, University of Paris 8, Paris, France

The gray mouse lemur (Microcebus murinus) is a small non-human primate with rapid maturity. This study focuses on the development of non-invasive MRI tools applied to neurodegenerative processes. We performed three different types of analysis: anatomical volumetric measures, neuronal network assessment with resting-state fMRI and brain glutamate distribution with gluCEST imaging. We found anatomical atrophy and functional deficiency mostly in cortical regions. To our knowledge, this study is the first to characterize the functional and anatomical brain aging process in a non-human primate. Furthermore, the mouse lemur functional and gluCEST maps have never been described before.

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