Abstract #3314

Fluorine-19 Magnetic Resonance at 21.1 Tesla to Detect Brain Inflammation

Sonia Waiczies¹, Jens T. Rosenberg², Christian Prinz¹, Ludger Starke¹, Jason M. Millward¹, Paula Ramos Delgado¹, Andreas Pohlmann¹, Andre Kuehne³, Helmar Waiczies³, and Thoralf Niendorf^1,4

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, ³MRI TOOLs GmbH, Berlin, Germany, ⁴Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center, Berlin, Germany

Detection of brain inflammation by fluorine-19 (¹⁹F) MRI was studied for the first time at 21.1 T (NHMFL, Tallahassee, FL). Studies on phantoms showed an SNR gain of 2.1 at 21.1 T, when compared to 9.4 T. A dependency between 19F-MR relaxation and magnetic field strength (B₀) was demonstrated. A T₁ reduction and higher SNR per unit time counterbalanced the T₂ shortening-induced loss in ¹⁹F MR signal when performing high spatially-resolved MRI of post mortem experimental autoimmune encephalomyelitis (EAE) mouse samples at 21.1 T. ¹⁹F-signals, not seen at 9.4 T, were revealed in both mouse brain and draining lymph nodes.

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