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Abstract #3314

Fluorine-19 Magnetic Resonance at 21.1 Tesla to Detect Brain Inflammation

Sonia Waiczies1, Jens T. Rosenberg2, Christian Prinz1, Ludger Starke1, Jason M. Millward1, Paula Ramos Delgado1, Andreas Pohlmann1, Andre Kuehne3, Helmar Waiczies3, and Thoralf Niendorf1,4

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 3MRI TOOLs GmbH, Berlin, Germany, 4Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center, Berlin, Germany

Detection of brain inflammation by fluorine-19 (19F) MRI was studied for the first time at 21.1 T (NHMFL, Tallahassee, FL). Studies on phantoms showed an SNR gain of 2.1 at 21.1 T, when compared to 9.4 T. A dependency between 19F-MR relaxation and magnetic field strength (B0) was demonstrated. A T1 reduction and higher SNR per unit time counterbalanced the T2 shortening-induced loss in 19F MR signal when performing high spatially-resolved MRI of post mortem experimental autoimmune encephalomyelitis (EAE) mouse samples at 21.1 T. 19F-signals, not seen at 9.4 T, were revealed in both mouse brain and draining lymph nodes.

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